abstract：:Laryngeal stridor is recognized as a characteristic clinical manifestation in patients with multiple system atrophy (MSA). However, the pathogenic mechanisms underlying this symptom are controversial. Neurogenic atrophy of the posterior cricoarytenoid muscle has been identified in cases of MSA, suggesting that larynge...

journal_title：Journal of the neurological sciences

authors： Ozawa T,Sekiya K,Aizawa N,Terajima K,Nishizawa M

更新日期：2016-02-15 00:00:00

abstract：INTRODUCTION:Functional movement disorders (FMD) are not associated with the kind of structural or biochemical alterations seen in other movement disorders and therefore would be unlikely to be associated with lower urinary tract (LUT) dysfunction. However, LUT symptoms have been observed in patients with FMD. OBJECTI...

journal_title：Journal of the neurological sciences

authors： Batla A,Pareés I,Edwards MJ,Stamelou M,Bhatia KP,Panicker JN

更新日期：2016-02-15 00:00:00

abstract：BACKGROUND:A specific non-motor impairment in Parkinson's disease (PD) concerns difficulties to accurately identify facial emotions. Findings are numerous but very inconsistent, ranging from general discrimination deficits to problems for specific emotions up to no impairment at all. By contrast, only a few studies exi...

journal_title：Journal of the neurological sciences

authors： Ille R,Wabnegger A,Schwingenschuh P,Katschnig-Winter P,Kögl-Wallner M,Wenzel K,Schienle A

更新日期：2016-02-15 00:00:00

abstract：BACKGROUND:Blocking the activity of IL-12/23 can inhibit autoimmune diseases such as psoriasis. OBJECTIVE:We examined whether an antibody against IL-12/23, ustekinumab (UTZ) (Stelera®), used clinically in psoriasis would have similar anti-inflammatory effects in EAE after oral administration. DESIGN/METHODS:B6 mice w...

journal_title：Journal of the neurological sciences

authors： Brod SA

更新日期：2016-02-15 00:00:00

abstract：:The neurobiological mechanisms underlying the development of post-traumatic stress disorder (PTSD) remain elusive. One of the hypotheses is the dysfunction of serotonin (5-HT) neurotransmission, which is critically regulated by serotonin transporter (SERT). Therefore, we hypothesized that attenuation of SERT gene expr...

journal_title：Journal of the neurological sciences

authors： Wu ZM,Zheng CH,Zhu ZH,Wu FT,Ni GL,Liang Y

更新日期：2016-01-15 00:00:00

abstract：PURPOSE:To investigate the relationship between linear lesions (LL) and the development of longitudinally extensive spinal cord lesions (LESCL) in Chinese patients with neuromyelitis optica or longitudinally extensive transverse myelitis. METHOD:The clinical records of 143 patients with these conditions were reviewed....

journal_title：Journal of the neurological sciences

authors： Cai W,Tan S,Zhang L,Shan Y,Wang Y,Lin Y,Zhou F,Zhang B,Chen X,Zhou L,Wang Y,Huang X,Men X,Li H,Qiu W,Hu X,Lu Z

更新日期：2016-01-15 00:00:00

abstract：OBJECTIVE:It has been suggested that autoantibodies may induce axonal damage in multiple sclerosis (MS). Optical coherence tomography (OCT) showed that thinning of peripapillary retinal nerve fiber layer (RNFL) and ganglion cell layer/inner plexiform (GCIPL) measurements reflect axonal loss in the disease. We investiga...

journal_title：Journal of the neurological sciences

authors： Álvarez-Cermeño JC,Muñoz-Negrete FJ,Costa-Frossard L,Sainz de la Maza S,Villar LM,Rebolleda G

更新日期：2016-01-15 00:00:00

abstract：PURPOSE:To investigate the direct and indirect associations of sleep hygiene with daytime sleepiness, depressive symptoms, and quality of life (QoL), in newly diagnosed, untreated patients with mild obstructive sleep apnea (OSA). METHODS:Data were collected from adults with mild OSA. The Sleep Hygiene Index (SHI), Sle...

journal_title：Journal of the neurological sciences

authors： Lee SA,Paek JH,Han SH

更新日期：2015-12-15 00:00:00

abstract：PURPOSE:Among different seizure types, tonic-clonic seizures are more significant because they are more often associated with morbidity. No prior study has been done to investigate risk factors associated with tonic-clonic seizures in patients with mesial temporal epilepsy. METHODS:In this retrospective study, all dru...

journal_title：Journal of the neurological sciences

authors： Asadi-Pooya AA,Rostami C,Rabiei AH,Sperling MR

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized by the involvement of cerebral small arteries. Although cerebral large artery disease has been reported in CADASIL patients, the prevalence and location of relevant cerebral arterial disease ...

journal_title：Journal of the neurological sciences

authors： Kang HG,Kim JS

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:Intracerebral hemorrhage (ICH) growth is an important independent predictor of clinical deterioration and outcome. Little is known about the association between etiology of ICH and occurrence of hematoma expansion (HE). The aim of the present study was to assess whether ICH etiologic subtype may influence th...

journal_title：Journal of the neurological sciences

authors： Cappellari M,Zivelonghi C,Moretto G,Micheletti N,Carletti M,Tomelleri G,Bovi P

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:Although most patients with Parkinson's disease (PD) show decreased cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake, some exhibit normal uptake. We evaluated the clinical characteristics of such patients. METHODS:We enrolled 154 non-demented patients showing parkinsonism with normal cardiac MIBG uptake...

journal_title：Journal of the neurological sciences

authors： Mizutani Y,Ito S,Murate K,Hirota S,Fukui T,Hikichi C,Ishikawa T,Shima S,Ueda A,Kizawa M,Asakura K,Mutoh T

更新日期：2015-12-15 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the morphologic magnetic resonance imaging (MRI) characteristics of the pineal gland in retinoblastoma (Rb) patients without and with pineoblastoma in comparison to age-matched controls to improve early identification of pineoblastomas (trilateral retinoblastoma, TRb). ...

journal_title：Journal of the neurological sciences

authors： Pham TT,Siebert E,Asbach P,Willerding G,Erb-Eigner K

更新日期：2015-12-15 00:00:00

abstract：OBJECTIVE:To provide an improved method for the identification and analysis of brain tumors in MRI scans using a semi-automated computational approach, that has the potential to provide a more objective, precise and quantitatively rigorous analysis, compared to human visual analysis. BACKGROUND:Self-Organizing Maps (S...

journal_title：Journal of the neurological sciences

authors： Mei PA,de Carvalho Carneiro C,Fraser SJ,Min LL,Reis F

更新日期：2015-12-15 00:00:00

abstract：BACKGROUND:Natalizumab therapy reduces inflammation and degeneration of the CNS in relapsing-remitting multiple sclerosis (RRMS). In cerebrospinal fluid (CSF) the concentration of 24S-hydroxycholesterol (24OHC) reflect neurodegeneration, whereas 27-hydroxycholesterol (27OHC) is dependent on the integrity of the blood-b...

journal_title：Journal of the neurological sciences

authors： Novakova L,Axelsson M,Malmeström C,Zetterberg H,Björkhem I,Karrenbauer VD,Lycke J

更新日期：2015-11-15 00:00:00

abstract：PURPOSE:The goal of the present study was to clarify the clinical characteristics and laboratory results of parkinsonian symptoms among patients with and without camptocormia. METHODS:Seventy-eight Parkinson's disease (PD) patients with camptocormia and 78 PD patients without camptocormia underwent a neurological exam...

journal_title：Journal of the neurological sciences

authors： Nakane S,Yoshioka M,Oda N,Tani T,Chida K,Suzuki M,Funakawa I,Inukai A,Hasegawa K,Kuroda K,Mizoguchi K,Shioya K,Sonoda Y,Matsuo H

更新日期：2015-11-15 00:00:00

abstract：BACKGROUND:Myasthenia gravis (MG) is the autoimmune disorder in which the thymus is considered the pathogenic organ. Thymectomy (TE) is a therapeutic option for MG and often ameliorates clinical symptoms. METHODS:We evaluated clinical features and outcomes after TE in patients without thymoma and the influence of TE w...

journal_title：Journal of the neurological sciences

authors： Jakubíková M,Piťha J,Marečková H,Týblová M,Nováková I,Schutzner J

更新日期：2015-11-15 00:00:00

abstract：INTRODUCTION:Although cerebral small vessel disease is a significant contributor to the development of imbalance and falls in the elderly, whether it causes dizziness is not known. METHODS:A retrospective case analysis was conducted for 122 dizzy patients referred to two neuro-otology tertiary centres in London and Pi...

journal_title：Journal of the neurological sciences

authors： Ahmad H,Cerchiai N,Mancuso M,Casani AP,Bronstein AM

更新日期：2015-11-15 00:00:00

abstract：BACKGROUND:This meta-analysis evaluated feasibility and efficacy of long-term whole-body vibration (WBV) training in improving mobility of multiple sclerosis (MS) patients. METHODS:The primary search of this meta-analysis was conducted from four electronic databases (PubMed, Sport, CINAHL and Cochrane) in order to fin...

journal_title：Journal of the neurological sciences

authors： Kantele S,Karinkanta S,Sievänen H

更新日期：2015-11-15 00:00:00

abstract：BACKGROUND:Tumefactive demyelinating lesions (TDLs) are associated with a variety of demyelinating diseases in the central nervous system (CNS). However, there are no current guidelines describing how to classify and treat patients with this rare phenotype. Thus, the present study aimed to determine the long-term evolu...

journal_title：Journal of the neurological sciences

authors： Jeong IH,Kim SH,Hyun JW,Joung A,Cho HJ,Kim HJ

更新日期：2015-11-15 00:00:00

abstract：BACKGROUND:Microglial activation is thought to be a key pathophysiological mechanism underlying disease activity in all forms of MS. Hydroxychloroquine (HCQ) is an antimalarial drug with immunomodulatory properties that is widely used in the treatment of rheumatological diseases. In this series of experiments, we explo...

journal_title：Journal of the neurological sciences

authors： Koch MW,Zabad R,Giuliani F,Hader W Jr,Lewkonia R,Metz L,Wee Yong V

更新日期：2015-11-15 00:00:00

abstract：OBJECTIVE:The purpose of this study was to clarify the difference between PSP and PD from the viewpoint of dynamic cerebrospinal fluid (CSF) flow focusing on the midbrain aqueduct. METHODS:Thirty-three PD patients (mean age 69.2±7.9) and 35 PSP patients (mean age 70.5±6.6) were included in this study. CSF flow was cal...

journal_title：Journal of the neurological sciences

authors： Fukui Y,Hishikawa N,Sato K,Yunoki T,Kono S,Matsuzono K,Nakano Y,Ohta Y,Yamashita T,Deguchi K,Abe K

更新日期：2015-10-15 00:00:00

abstract：BACKGROUND:Although adoption of new clinical criteria for dementia with Lewy bodies (DLB) leads to an increase in the proportion of patients diagnosed with probable DLB, the sensitivity of clinical diagnostic criteria of DLB is low, and there are no generally accepted clinical or imaging biomarkers to distinguish DLB f...

journal_title：Journal of the neurological sciences

authors： Kim JS,Park HE,Oh YS,Song IU,Yang DW,Park JW,Lee KS

更新日期：2015-10-15 00:00:00

abstract：OBJECTIVE:To describe the neurological and neuroradiological features of acquired hemophagocytic lymphohistiocytosis (HLH) in adulthood by reporting a series of cases. METHODS:Ten consecutive patients who were diagnosed with HLH at Medstar Georgetown University Hospital and Walter Reed National Military Medical Center...

journal_title：Journal of the neurological sciences

authors： Gratton SM,Powell TR,Theeler BJ,Hawley JS,Amjad FS,Tornatore C

更新日期：2015-10-15 00:00:00

abstract：:Hemifacial spasm is characterised by unilateral contractions of the facial muscles. Though considered to be benign by many people, it can lead to functional blindness and a poor quality of life due to social embarrassment for the suffering individual. Botulinum toxin therapy is an excellent noninvasive tool to treat t...

journal_title：Journal of the neurological sciences

authors： Chaudhry N,Srivastava A,Joshi L

更新日期：2015-09-15 00:00:00

abstract：INTRODUCTION:The underlying pathophysiology of neurological complications in patients with hemolytic-uremic syndrome (HUS) remains unclear. It was recently attributed to a direct cytotoxic effect of Shiga toxin 2 (Stx2) in the thalamus. Conventional MRI of patients with Stx2-caused HUS revealed - despite severe neurolo...

journal_title：Journal of the neurological sciences

authors： Krämer J,Deppe M,Göbel K,Tabelow K,Wiendl H,Meuth SG

更新日期：2015-09-15 00:00:00

abstract：:Hypnic headache (HH) is a rare benign disorder described initially by Raskin in 1988. It is characterized by recurrent nocturnal episodes of headache that periodically awaken the sleeping patient and usually occur in the elderly. This review is aimed at describing the clinical features of the HH cases in childhood tha...

journal_title：Journal of the neurological sciences

authors： Silva-Néto RP,Almeida KJ

更新日期：2015-09-15 00:00:00

abstract：:Hypereosinophilic syndrome represents a rare cause for cerebral infarctions and inflammatory neurological disorders. Various possible pathogenic mechanisms for cerebral infarctions have already been discussed. Complex mechanisms including a local hypercoagulability by eosinophilic granules as well as a direct damage t...

journal_title：Journal of the neurological sciences

authors： Bolz J,Meves SH,Kara K,Reinacher-Schick A,Gold R,Krogias C

更新日期：2015-09-15 00:00:00

abstract：OBJECTIVE:GM1 ganglioside has been suggested as a treatment for Parkinson's disease (PD), potentially having symptomatic and disease modifying effects. The current pilot imaging study was performed to examine effects of GM1 on dopamine transporter binding, as a surrogate measure of disease progression, studied longitud...

journal_title：Journal of the neurological sciences

authors： Schneider JS,Cambi F,Gollomp SM,Kuwabara H,Brašić JR,Leiby B,Sendek S,Wong DF

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Mild cognitive impairment (MCI) is a well-known precursor of Alzheimer's disease (AD) but often also precedes dementia with Lewy bodies (DLB). The early differentiation of DLB from AD is important to delay disease progression. Olfactory dysfunction is a well-known early sign of both AD and Lewy body disorder...

journal_title：Journal of the neurological sciences

authors： Yoon JH,Kim M,Moon SY,Yong SW,Hong JM

更新日期：2015-08-15 00:00:00

abstract：OBJECT:The aim of this study is to identify pre-operative clinical and/or radiological predictors of clinical failure of decompressive hemicraniectomy (DH) in the setting of malignant hemispheric infarction. These predictors could guide the decision for adjunctive internal brain decompression (e.g. strokectomy) at the ...

journal_title：Journal of the neurological sciences

authors： Merenda A,Perez-Barcena J,Frontera G,Benveniste RJ

更新日期：2015-08-15 00:00:00

abstract：:The aim of this study was to review the epidemiological and clinical characteristics of neuromyelitis optica (NMO) and the immunopathological mechanisms involved in the neuronal damage. NMO is an inflammatory demyelinating autoimmune disease of the central nervous system that most commonly affects the optic nerves and...

journal_title：Journal of the neurological sciences

authors： Pereira WL,Reiche EM,Kallaur AP,Kaimen-Maciel DR

更新日期：2015-08-15 00:00:00

abstract：BACKGROUND:Glial cell activation and endothelial dysfunction are thought to contribute to the pathophysiology of cerebral small vessel disease (SVD). The purpose of the present study was to determine if levels of S100B, a protein highly expressed in glial cells, and asymmetric dimethylarginine (ADMA), which promotes en...

journal_title：Journal of the neurological sciences

authors： Gao Q,Fan Y,Mu LY,Ma L,Song ZQ,Zhang YN

更新日期：2015-07-15 00:00:00

abstract：:Altered functional connectivity has been associated with the influence of epileptic activity. Abnormalities in connectivity, particularly in dorsal attention (DAN), salience (SN) and default mode (DMN) networks, might contribute to the loss of consciousness during seizures and cognitive deficits in patients with child...

journal_title：Journal of the neurological sciences

authors： Li Q,Cao W,Liao X,Chen Z,Yang T,Gong Q,Zhou D,Luo C,Yao D

更新日期：2015-07-15 00:00:00

abstract：:Mutations in COL4A1, encoding one of the six collagen type IV proteins, cover a wide spectrum of autosomal dominant overlapping phenotypes including porencephaly, small-vessel disease and hemorrhagic stroke, leukoencephalopathy, hereditary angiopathy with nephropathy, aneurysms and muscle cramp (HANAC) syndrome, and W...

journal_title：Journal of the neurological sciences

authors： Giorgio E,Vaula G,Bosco G,Giacone S,Mancini C,Calcia A,Cavalieri S,Di Gregorio E,Rigault De Longrais R,Leombruni S,Pinessi L,Cerrato P,Brusco A,Brussino A

更新日期：2015-05-15 00:00:00

abstract：BACKGROUND:Treatment options for neuromyelitis optica (NMO) are currently based on small retrospective case series and open label studies, ranging from 10 to 103 patients. OBJECTIVE:To compare the efficacy and tolerability of azathioprine, cyclophosphamide, mycophenolate, and rituximab in patients with neuromyelitis o...

journal_title：Journal of the neurological sciences

authors： Torres J,Pruitt A,Balcer L,Galetta S,Markowitz C,Dahodwala N

更新日期：2015-04-15 00:00:00

abstract：PURPOSE:Paroxysmal kinesigenic dyskinesia (PKD) is a rare movement disorder. The underlying neural mechanisms have not been fully understood. This study aimed to examine the alteration of resting-state functional connectivity (RSFC) between interhemispheric homotopic regions in PKD using a technique called "voxel-mirro...

journal_title：Journal of the neurological sciences

authors： Ren J,Lei D,Yang T,An D,Xiao F,Li L,Huang X,Gong Q,Zhou D

更新日期：2015-04-15 00:00:00

abstract：:Interaction of the orexinergic (ORXergic) neuronal system with the excitatory (glutamate, l-Glu) or the inhibitory (GABA) neurosignaling complexes evokes major homeostatic physiological events. In this study, effects of the two ORXergic neuropeptides (ORX-A/B) on their receptor (ORX-2R) expression changes were correla...

journal_title：Journal of the neurological sciences

authors： Alò R,Avolio E,Mele M,Di Vito A,Canonaco M

更新日期：2015-04-15 00:00:00

abstract：PURPOSE:To investigate localized cerebral function abnormalities in patients with familial cortical myoclonic tremor and epilepsy (FCMTE) using resting-state functional magnetic resonance imaging (fMRI). METHODS:Seven patients with FCMTE from a Chinese family, seven patients with essential tremor (ET), and ten healthy...

journal_title：Journal of the neurological sciences

authors： Wang P,Luo C,Dong L,Bin Y,Ma S,Yao D,Guo F,Yang Z

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND AND PURPOSE:Pure midbrain stroke can cause isolated unilateral oculomotor paresis. We attempted to determine whether there is a difference in the oculomotor paresis pattern between pure midbrain infarction and midbrain hemorrhage. METHODS:Pure midbrain stroke patients who presented with isolated unilateral ...

journal_title：Journal of the neurological sciences

authors： Amano Y,Kudo Y,Kikyo H,Imazeki R,Yamamoto M,Amari K,Tanaka F,Johkura K

更新日期：2015-04-15 00:00:00